Faculty Information |
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Article types | Original article |
Language | English |
Refereed paper | Refereed |
Title | Demography and Treatment Response in Patients with Predominant Non-erosive Reflux Disease or Functional Dyspepsia. |
Journal | Formal name:Journal of gastroenterology and hepatology Abbreviation:J Gastroenterol Hepatol ISSN code:1440-1746(Electronic)0815-9319(Linking) |
Volume, Number, Page | 30(5),pp.834-41 |
Papers・Author | Miwa Hiroto, Haruma Ken, Sakamoto Shigeru, Sanada Katsuyuki, Hiroi Shinzo, Kinoshita Yoshikazu |
Publication date | 2015/01 |
Papers・Description | BACKGROUND AND AIM:Non-erosive reflux disease (NERD) and functional dyspepsia (FD) share some common features, and the appropriateness of managing these diseases independently has been questioned. A post hoc subgroup analysis of the LEGEND study was performed to compare demographics and treatment response between patients with NERD or FD.METHODS:PatientsMETHODS:with reflux and dyspepsia symptoms who had no endoscopic evidence of mucosal breaks and/or erosions were included, and divided into groups with predominant NERD (n = 1546) or FD (n = 614). Patients received lansoprazole for 4 weeks and their symptoms were evaluated using questionnaires.RESULTS:FD patients were significantly younger than NERD patients (54 vs. 60 years), more likely to have a body mass indexRESULTS:<RESULTS:25 kg/m2 (72.4% vs. 67.1%), less likely to have a hiatal hernia (24.0% vs. 31.2%), and more likely to feel continuous stress (54.7% vs. 48.0%). After 4 weeks' treatment,RESULTS:>RESULTS:60% of both patients reported an improvement in reflux symptoms and in most dyspepsia symptoms. The improvement rate for reflux symptoms was lower in FD patients than in NERD patients (PRESULTS:<RESULTS:0.05), whereas the improvement rate for dyspepsia symptoms did not differ between patient groups.CONCLUSIONS:Although no clinically significant differences in pathophysiology exist between NERD and FD, there are some between-group differences in demographic characteristics and improvement rates for reflux symptoms after treatment with lansoprazole. It remains to be discussed whether it is necessary to make a strict differential diagnosis between these two conditions. |
DOI | 10.1111/jgh.12877 |
PMID | 25559435 |