教員業績データベース |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読なし |
表題 | Crohn's disease complicated by hepatitis B virus successfully treated with the use of adsorptive depletion of myeloid lineage leucocytes to suppress inflammatory cytokine profile. |
掲載誌名 | 正式名:Cytotherapy 略 称:Cytotherapy ISSNコード:1477-2566(Electronic)1465-3249(Linking) |
巻・号・頁 | 16(6),pp.821-5 |
著者・共著者 | Yokoyama Yoko, Fukunaga Ken, Kamikozuru Koji, Sato Toshiyuki, Kawai Mikio, Nogami Koji, Nagase Kazuko, Nakamura Misaki, Immured Masaki, Hida Nobuyuki, Nakamura Shiro |
発行年月 | 2014/06 |
概要 | BACKGROUND AIMS:In patients with inflammatory bowel disease infected with hepatitis B virus (HBV), immunosuppressive therapy required to suppress active inflammatory bowel disease may promote HBV reactivation.METHODS:A 27-year-old corticosteroid-naive woman with Crohn's disease (CD) activity index of 249.8 complicated by HBV infection was offered Entecavir to control HBV reactivation during immunosuppressive therapy for CD. The patient refused EMETHODS:ntecavir, fearing that it might adversely affect her pregnancy outcome. Instead, we applied intensive granulocyte/monocyte adsorptive apheresis (GMA) at two sessions per week to deplete inflammatory cytokine-producing leucocytes as an immunosuppressive therapy in this case.RESULTS:GMA induced stable remission (CD activity index, I 105) and endoscopic improvement without HBV reactivation or safety concern. Furthermore, CD remission was paralleled by suppression of tumor necrosis factor and interleukin as measured in serum samples.CONCLUSIONS:Immunosuppressive therapy required to treat an active CD potentially can promote HBV reactivation and worsen liver function. In this study involving a CD case complicated by chronic HBV infection, intensive GMA as a non-pharmacologic treatment intervention was associated with clinical remission and endoscopic improvement without HBV reactivation. Furthermore, GMA was well-tolerated and was without any safety concern. However, suppression of tumor necrosis and interleukin-6by GMA in this clinical setting is potentially very interesting. |
DOI | 10.1016/j.jcyt.2014.01.009 |
PMID | 24713332 |