Faculty Information |
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Article types | Original article |
Language | English |
Refereed paper | Not refereed |
Title | Xilei san ameliorates experimental colitis in rats by selectively degrading proinflammatory mediators and promoting mucosal repair. |
Journal | Formal name:Evidence-based complementary and alternative medicine : eCAM Abbreviation:Evid Based Complement Alternat Med ISSN code:1741-427X(Print)1741-427X(Linking) |
Volume, Number, Page | 2014,pp.569587 |
Papers・Author | Hao Yongbiao, Nagase Kazuko, Hori Kazutoshi, Wang Shenglan, Kogure Yoko, Fukunaga Ken, Kashiwamura Shinichiro, Yamamoto Satoshi, Nakamura Shiro, Li Junxiang, Miwa Hiroto, Noguchi Koichi, Dai Yi |
Publication date | 2014 |
Papers・Description | Xilei san (XLS), a herbal preparation widely used in China for erosive and ulcerative diseases, has been shown to be effective in ulcerative colitis (UC). The present experiments were conducted to assess its efficacy and determine its mechanism of action in a rat model that resembles human UC. The model was induced by adding 4% dextran sulfate sodium (DSS) to the rats' drinking water for 7 days. XLS was administered daily by retentionenema from day 2 to day 7; the rats were sacrificed on day 8. The colon tissues were obtained for further experiments. A histological damage score and the activity of tissue myeloperoxidase were used to evaluate the severity of the colitis. The colonic cytokine levels were detected in a suspension array, and epithelial proliferation was assessed using Ki-67 immunohistochemistry. Intrarectal administration of XLS attenuated the DSS-induced colitis, as evidenced by a reduction in both the histological damage score and myeloperoxidase activity. It also decreased the levels of proinflammatory cytokines, but increased the mucosal repair-related cytokines. In addition, the epithelial Ki-67 expression was upregulated by XLS. These results suggest that XLS attenuates DSS-induced colitis by degrading proinflammatory mediators and promoting mucosal repair. XLS could be a potential topical treatment for human UC. |
DOI | 10.1155/2014/569587 |
PMID | 25120575 |