Faculty Information |
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Article types | Introduction |
Language | English |
Refereed paper | Not refereed |
Title | Validity of low-intensity continuous renal replacement therapy*. |
Journal | Formal name:Critical care medicine Abbreviation:Crit Care Med ISSN code:1530-0293(Electronic)0090-3493(Linking) |
Volume, Number, Page | 41(11),pp.2584-91 |
Papers・Author | Uchino Shigehiko, Toki Noriyoshi, Takeda Kenta, Ohnuma Tetsu, Namba Yoshitomo, Katayama Shinshu, Kawarazaki Hiroo, Yasuda Hideto, Izawa Junichi, Uji Makiko, Tokuhira Natsuko, Nagata Isao |
Publication date | 2013/11 |
Papers・Description | OBJECTIVE:To study the hospital mortality of patients with severe acute kidney injury treated with low-intensity continuous renal replacement therapy.DESIGN:Multicenter retrospective observational study (Japanese Society for Physicians and Trainees in Intensive Care), combined with previously conducted multinational prospective observational study (Beginning and Ending Supportive Therapy).SETTING:Fourteen Japanese ICUs in 12 tertiary hospitals (Japanese Society for Physicians and Trainees in Intensive Care) and 54 ICUs in 23 countries (Beginning and Ending Supportive Therapy).PATIENTS:Consecutive adult patients with severe acute kidney injury requiring continuous renal replacement therapy admitted to the participating ICUs in 2010 (Japanese Society for Physicians and Trainees in Intensive Care, n = 343) and 2001 (Beginning and Ending Supportive Therapy Beginning and Ending Supportive Therapy, n = 1,006).INTERVENTIONS:None.MEASUREMENTS AND MAIN RESULTS:Patient characteristics, variables at continuous renal replacement therapy initiation, continuous renal replacement therapy settings, and outcomes (ICU and hospital mortality and renal replacement therapy requirement at hospital discharge) were collected. Continuous renal replacement therapy intensity was arbitrarily classified into seven subclasses: less than 10, 10-15, 15-20, 20-25, 25-30, 30-35, and more than 35 mL/kg/hr. Multivariable logistic regression analysis was conducted to investigate risk factors for hospital mortality. The continuous renal replacement therapy dose in the Japanese Society for Physicians and Trainees in Intensive Care database was less than half of the Beginning and Ending Supportive Therapy database (800 mL/hr vs 2,000 mL/hr, pMEASUREMENTS AND MAIN RESULTS:<MEASUREMENTS AND MAIN RESULTS:0.001). Even after adjusting for the body weight and dilution factor, continuous renal replacement therapy intensity was statistically different (14.3 mL/kg/hr vs 20.4 mL/kg/hr, pMEASUREMENTS AND MAIN RESULT |
DOI | 10.1097/CCM.0b013e318298622e |
The document number | 23939357 |