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  3. Division of Gastroenterology Department of Internal Medicine

< Previous 2017 Academic yr 2018 Academic yr 2019 Academic yr Next >
 Division of Gastroenterology Department of Internal Medicine



 :
    Miwa Hiroto    Watari Jiro
 :
    Fukui Hirokazu
 :
    Oshima Tadayuki
 :
    Eda Hirotsugu    Ogawa Tomohiro    Okugawa Takuya    Kondo Takashi    Tamura Akio    Tozawa Katsuyuki    Nakamura Kumiko    Michigami Yuuki    Yamasaki Takahisa
■ List of number of research achievements in that year
Journal Book Presentation Other presentations
JapaneseEnglish JapaneseEnglish Domesticinternational
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 8 0 8  4 5 14  0 0 0 0  5 1 1 6  4 6
■ Journal
Original article
1. Xu Xin, Fukui Hirokazu, Ran Ying, Tomita Toshihiko, Oshima Tadayuki, Watari Jiro, Miwa Hiroto.Alteration of GLP-1/GPR43 expression and gastrointestinal motility in dysbiotic mice treated with vancomycin.CIENTIFIC REPORTS 2019;(41598):1-10
2. Horikawa Tomoki, Oshima Tadayuki, Li Min, Kitayama Yoshitaka, Eda Hirotdugu, Nakamura Kumiko, Tamura Akio, Ogawa Tomohiro, Yamasaki Takahisa, Okugawa Takuya, Kondo Takashi, Kono Tomoaki, Tozawa Katsuyuki, Tomita Toshihiko, Fukui Hirokazu, Watari Jiro, Miwa Hiroto.Chenodeoxycholic Acid Releases Proinflammatory Cytokines from Small Intestinal Epithelial Cells Through the Farnesoid X Receptor. Digestion.Digestion 2019;1159(000496687):1-9
3. Taki Masato, Oshima Tadayuki, Li Min, Sei Hiroo, Tozawa Katsuyuki, Tomita Toshihiko, Fukui Hirokazu, Watari Jiro, Miwa Hiroto.Duodenal low-grade inflammation and expression of tight junction proteins in functional dyspepsia.Neurogastroenterology & Motility 2019;(13576):1-7
4. Inoue Yoshihito, Fukui Hirokazu, Xu Xin, Ran Ying, Tomita Toshihiko, Oshima Tadayuki, Watari Jiro, Miwa Hiroto.Colonic M1 macrophage is associated with the prolongation of gastrointestinal motility and obesity in mice treated with vancomycin.MOLECULAR MEDICINE REPORTS 2019;10(3892):2591-2598
5. Miwa Hiroto, Oshima Tadayuki, Tomita Toshihiko, Fukui Hirokazu, Kondo Takashi, Yamasaki Takahisa, Watari Jiro.Recent understanding of the pathophysiology of functional dyspepsia: role of the duodenum as the pathogenic center. Journal of Gastroenterology.The Japanese Society of Gastroenterology 2019;(00535):1-7
6. Kosako Masanori, Akiho Hikaru, Miwa Hiroto, Kanazawa Motoyori, Fukudo Shin.Influence of the requirement for abdominal pain in the diagnosis of irritable bowel syndrome with constipation (IBS-C) under the Rome IV criteria using data from a large Japanese population – based internet survey.BioPsychoSocial Medicine 2018;(13030):018-0137
7. Oshima Tadayuki, Arai Eitatsu, Taki Masato, Kondo Takashi, Tomita Toshihiko, Fukui Hirokazu, Watari Jiro, Miwa Hiroto.Randomised clinical trial: vonoprazan versus lansoprazole for the initial relief of heartburn in patients with erosive oesophagitis.Alimentary Pharmacology & Therapeutics 2018;(15062):140-146
8. Tomita Toshihiko, Oshima Tadayuki, Miwa Hiroto.New Approaches to Diagnosis and Treatment of Functional Dyspepsia.Current Gastroenterology Reports 2018;20(55):12-18
9. Wu Liping, Oshima Tadayuki, Li Min, Tomita Toshihiko, Fukui Hirokazu, Watari Jiro, Miwa Hiroto.Filaggrin and tight junction proteins are crucial for IL-13-mediated esophageal barrier dysfunction.American journal of physiology. Gastrointestinal and liver physiology 2018;315(3):G341-G350
10. Nakai Keisuke, Watari Jiro, Tozawa Katsuyuki, Tamura Akio, Hara Ken, Yamasaki Takahisa, Kondo Takashi, Kono Tomoaki, Tomita Toshihiko, Ohda Yoshio, Oshima Tadayuki, Fukui Hirokazu, Sakurai Jun, Kim Yongmin, Hayakawa Yuji, Fujisawa Takashi, Morimoto Takeshi, Miwa Hiroto.Sex differences in associations among metabolic syndrome, obesity, related biomarkers, and colorectal adenomatous polyp risk in a Japanese population.Journal of Clinical Biochemistry and Nutrition 2018;63(2):154-163
11. Fukudo Shin, Miwa Hiroto, Nakajima Atsushi, Kinoshita Yoshikazu, Kosako masanori, Hayashi Kenta, Akiho Hiraku, Kuroishi Kentaro, Jeffrey M Johnston, Mark Currie, Ohkusa Toshifumi.High Dose Linaclotide Is Effective and Safe in Patients with Chronic Constipation: A Phase III Randomized, Double-Blind, Placebo-Controlled Study with a Long-Term Open-Label Extension Study in Japan.Neurogastroenterology & Motility 2018;(13487):1-13
12. Michigami Yuki, Watari Jiro, Ito Chiyomi, Nakai Keisuke, Yamasaki Takahisa, Kondo Takashi, Kono Tomoaki, Tozawa Katsuyuki, Tomita Toshihiko, Oshima Tadayuki, Fukui Hirokazu, Morimoto Takeshi, Das Kiron M., Miwa Hiroto.Long-term effects of H. pylori eradication on epigenetic alterations related to gastric carcinogenesis.SCIENTIFIC REPORTS 2018;25(8):1-13
13. Fukui Hirokazu, Oshima Tadayuki, Tanaka Yoshiki, Oikawa Yosuke, Makizaki Yutaka, Ohno Hiroshi, Tomita Toshihiko, Watari Jiro, Miwa Hiroto.Effect of probiotic Bifidobacterium bifidum G9-1 on the relationship between gut microbiota profile and stress sensitivity in maternally separated rats.SCIENTIFIC REPORTS 2018;17(8):1-10
14. Watari Jiro, Kobayashi Masaya, Nakai Keisuke, Ito Chiyomi, Tamura Akio, Ogawa Tomohiro, Yamasaki Takahisa, Okugawa Takuya, Kondo Takashi, Kono Tomoaki, Tozawa Katsuyuki, Tomita Toshihiko, Oshima Tadayuki, Fukui Hirokazu, Morimoto Takeshi, Miwa Hiroto.Objective image analysis of non-magnifying image-enhanced endoscopy for diagnosis of small depressed early gastric cancers.Endoscopy International Open 2018;6(12):1445-1453
15. Ishigami Hironori, Fujiwara Yoshiyuki, Fukushima Ryoji, Nashimoto Atsushi, Yabusaki Hiroshi, Imano Motohiro, Imamoto Haruhiko, Kodera Yasuhiro, Uenosono Yoshikazu, Amagai Kenji, Kadowaki Shigenori, Miwa Hiroto, Yamaguchi Hironori, Yamaguchi Takuhiro, Miyaji Tempei, Kitayama Joji.Phase III Trial Comparing Intraperitoneal and Intravenous Paclitaxel PlusS-1 Versus Cisplatin Plus S-1 in Patients With Gastric Cancer With Peritoneal Metastasis: PHOENIX-GC Trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2018;36(19):1922-1929
16. Oshima Tadayuki, Miwa Hiroto.Potent Potassium-competitive Acid Blockers: A New Era for the Treatment of Acid-related Diseases.Journal of neurogastroenterology and motility 2018;24(3):334-344
17. Fukui Hirokazu, Xu Xin, Miwa Hiroto.Role of Gut Microbiota-Gut Hormone Axis in the Pathophysiology of Functional Gastrointestinal Disorders.Journal of neurogastroenterology and motility 2018;24(3):367-386
18. Fukudo Shin, Miwa Hiroto, Nakajima Atsushi, Haruma Ken, Kosako Masanori, Nakagawa Ayako, Akiho Hiraku, Yamaguchi Yusuke, Johnston Jeffrey M., Currie Mark, Kinoshita Yoshikazu.A randomized controlled and long-term linaclotide study of irritable bowel syndrome with constipation patients in Japan.Neurogastroenterol Motil 2018;(13444):1-12
19. Tominaga K, Sakata Y, Kusunoki H, Odaka T, Sakurai K, Kawamura O, Nagahara A, Takeuchi T, Fujikawa Y, Oshima T, Kato M, Furuta T, Murakami K, Chiba T, Miwa H, Kinoshita Y, Higuchi K, Kusano M, Iwakiri R, Fujimoto K, Tack J F, Arakawa T.Rikkunshito simultaneously improves dyspepsia correlated with anxiety in patients with functional dyspepsia: A randomized clinical trial (the DREAM study).Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2018;30(7):e13319
20. Kodani Mio, Fukui Hirokazu, Tomita Toshihiko, Oshima Tadayuki, Watari Jiro, Miwa Hiroto.Association between gastrointestinal motility and macrophage/mast cell distribution in mice during the healing stage after DSS-induced colitis.Molecular medicine reports 2018;17(6):8167-8172
21. Fukudo S, Nakajima A, Fujiyama Y, Kosako M, Nakagawa A, Akiho H, Nakashima Y, Johnston J M, Miwa H.Determining an optimal dose of linaclotide for use in Japanese patients with irritable bowel syndrome with constipation: A phase II randomized, double-blind, placebo-controlled study.Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2018;30(5):e13275
22. Fukudo S, Nakajima A, Fujiyama Y, Kosako M, Nakagawa A, Akiho H, Nakashima Y, Johnston J M, Miwa H.Randomized, double-blind, placebo-controlled study vs data in the daily practice using linaclotide in patients with irritable bowel syndrome with constipation.Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2018;30(5):e13363
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Introduction
1. 福井広一, 三輪洋人.慢性便秘症とは.SUZUKEN GROUP Suzuken Medical 2019;(特別):13-13
2. 富田寿彦, 三輪洋人.慢性便秘症.SUZUKEN GROUP Suzuken Medical 2019;(特別):4-6
3. 大島忠之, 三輪洋人.大島忠之, 三輪洋人.SUZUKEN GROUP Suzuken Medical 2019;(特別):7-10
4. 富田寿彦, 三輪洋人.慢性便秘症.SUZUKEN GROUP Suzuken Pharma 2019;(特別):6-6
5. 福井広一, 三輪洋人.慢性便秘症のくすり.SUZUKEN GROUP Suzuken Pharma 2019;(特別):７-７
6. 三輪洋人, 近藤隆.【機能性消化管疾患―概念と分類―】 特集 機能性消化管疾患診療の実際.日本医師会雑誌 2019;147(10):1997-2001
7. 富田寿彦, 三輪洋人.【慢性便秘症の診療の進歩】 慢性便秘の治療　膨張性下剤の使い方(解説/特集).日本内科学会雑誌 2019;108(1):29-35
8. 三輪洋人.特集：胃痛・胸やけ この病気？.NHK きょうの健康 2018;368(11):33-49
9. 大島忠之, 三輪 洋人.【ストレスを考慮した機能性ディスペプシア/胃食道逆流合併患者の診療】 小特集　機能性ディスペプシアの最新知見と新たな診療.消化器の臨床 2018;21(4):289-296
10. 三輪洋人.【便秘診療の最前線】 総論　新しい便秘診療の考え方(解説/特集).日本消化器病学会雑誌 2018;115(11):933-939
11. 富田寿彦, 森すみれ, 大島忠之, 福井広一, 渡二郎, 三輪洋人.【便秘（薬物治療）】 特集Ⅰ　機能性消化管疾患の治療.消化器・肝臓内科 2018;4(4):300-306
12. 福井広一, 三輪洋人.【早わかり内視鏡関連ガイドライン2018】 消化器全般におよぶもの　機能性消化管疾患診療ガイドライン　a.機能性ディスペプシア(FD)　b.過敏性腸症候群(IBS)(解説/特集).消化器内視鏡 2018;30(9):1244-1251
13. 近藤 隆, 三輪 洋人.【上部消化管疾患の現況と今後の展望-病態・診断から治療を探る】 機能性胸やけ、逆流性過敏症.カレントテラピー 2018;36(7):620-625
14. 福井 広一, 三輪 洋人.【透析医療と合併症　キュア&ケアガイドブック】 消化器(CQ 21)　GERDを合併した透析患者への対応はどのように行いますか?.臨床透析 2018;34(7):767-769
15. 福井 広一, 三輪 洋人.よく使う日常治療薬の正しい使い方　消化性潰瘍治療薬の使い方.レジデントノート 2018;20(3):431-433
16. 大島 忠之, 三輪 洋人.【GERD(胃食道逆流症)-病態と治療】 胃食道逆流症状の発現メカニズム.BIO Clinica 2018;33(4):310-314
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■ Presentation
International Society
1. Kitayama Y, Tozawa K, Fukui H, Hara K, Kondo T, Tomita T, Ohda Y, Oshima T, Watari J, Miwa H.Combination of neutrophil-to-lymphocyte ratio (NTR) and G8 screening tool is useful to predict overall survival of elderly patients with chemotherapy for unresectable/recurrent gastric cancer.(Poster Session) Digestive Disease Week(DDW2018) 2018.6 Washington,D.C.
2. Fukudo S, Miwa H, Nakajima A, Kinoshita Y, Kosako M, Hayashi K, Akiho H, Kuroishi K, Johnston J, Currie M, Ohkusa T.Linaclotide is effective and safe for patients with chronic constipation in Japan: A phase III randomized, double-blind, placebo-controlled study with a long-term open-label extension study.(Poster Session) Digestive Disease Week(DDW2018) 2018.6 Washington,D.C.
3. Oshima T, Arai E, Horikawa T, Taki M, Kondo T, Tomita T, Fukui H, Watari J, Miwa H.Double-blind, randomized trial of effects of vonoprazan and lansoprazole for the first seven days on relief of gastroesophageal reflux disease symtopms.(Research Forum Session) Digestive Disease Week(DDW2018) 2018.6 Washington,D.C.
4. Fukudo S, Nakamura M, Miwa H.Efficacy and safety of novel 5-HT4 agoinst DSP-6952 in patients with irritable bowel syndrome with constipation: a randomized, double-blind, placebo-controlled early phase II study.(Lecture) Digestive Disease Week(DDW2018) 2018.6 Washington,D.C.
5. Inoue Y, Fukui H, Xu X, Kondo T, Kono T, Tozawa K, Ohda Y, Tomita T, Oshima T, Watari J, Miwa H.Antibiotics treatment prolongs gastrointestinal transit time accompanted by increase of colonic GLP-1/GPR43 expression.(Poster Session) Digestive Disease Week(DDW2018) 2018.6 Washington, D.C.
6. Michigami Y, Watari J, Ito C, Kondo T, Kono T, Tozawa K, Tomita T, Oshima T, Fukui H, Miwa H.Long-term effects of H. pylori eradication on molecular alterations in precancerous lesions, atrophic mucosa and intestinal metaolasia.(Poster Session) Digestive Disease Week(DDW2018) 2018.6 Washington, D.C.
7. Miwa H.State-of the art lecture: Novel mechanism drugs and herbals for Functional Dyspepsia.(Research Forum Session) Digestive Disease Week(DDW2017) 2018.5 Chicago
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Domestic Society
1. 三輪洋人.慢性便秘症の診断と治療の考え方～新しいIBAT阻害薬の位置付けを含めて～.(ランチョンセミナ) 第60回日本老年医学会学術集会 2018.6 京都
2. 三輪洋人.機能性消化管障害：臨床の知と病態最前線.(企画シンポジウム) 第59回日本心身医学会総会ならびに学術講演会 2018.6 愛知
3. 三輪洋人.機能性ディスペプシア研究の最前線.(ランチョンセミナ) 第59回日本心身医学会総会ならびに学術講演会 2018.6 愛知
4. ◎福井 広一, 大島 忠之, 三輪 洋人.母子分離ラットモデルにおける腸内細菌叢と消化管機能に関する検討.(ワークショップ) 第104回日本消化器病学会総会 2018.4 東京
5. 富田寿彦.消化器内科医が行う胃癌化学療法のReal World-サイラムザ適正使用のポイントと高齢者胃癌に対する治療戦略-.(ランチョンセミナー) 第104回日本消化器病学会総会 2018.4 東京
6. ◎道上 祐己, 渡 二郎, 三輪 洋人.H.pylori除菌後長期経過例における胃癌抑制効果の分子病理学的検討.(パネルディスカッション) 第104回日本消化器病学会総会 2018.4 東京
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Local meetings
1. 吉本崇典, 江田裕嗣，河野友彰，富田寿彦，大島忠之，福井広一，渡　二郎，三輪洋人，岩見 久司, 五味 文.脈絡膜転移をきたした十二指腸癌術後再発の1例.(一般) 第220回日本内科学会近畿地方会 2018.6 大阪
2. ◎清　裕生, 富田　寿彦，渡　　二郎，三輪　洋人.当院における非乳頭部十二指腸腫瘍に対する内視鏡治療の現状.(シンポジウム) 第100回日本消化器内視鏡学会近畿支部例会 2018.5 大阪
3. ◎中井啓介,田村　彰朗，戎谷　信彦，戸澤　勝之，富田　寿彦，大島　忠之，福井　広一，渡　　二郎，三輪　洋人，倉橋　泰典，篠原　　尚，松田　育雄，廣田　誠一.HPV（Human papillomavirus）関連が疑われた若年性頸部進行食道癌の一例.(一般) 第100回日本消化器内視鏡学会近畿支部例会 2018.5 大阪
Meeting for the study, lecture
1. 三輪洋人.機能性ディスペプシアの最前線.(特別講演) 第34回相模消化器研究会 2018.7 神奈川
2. Tamura A, Tomita T, Inoue Y, Mori S, Nakai K, Kono T, Kondo T, Tozawa K, Oshima T, Fukui H, Watari J, Miwa H.A present status of the treatment for constipation before and after the publication of the clinical guidelines of chronic constipation in Japan.(Session) The 4th Japan - Thailand Functional Gastrointestinal Disease Conference 2018.7 Nagoya
3. Inoue Y, Fukui H, Mori S, Nakai K, Tamura A, Kono T, Kondo T, Tozawa K, Tomita T, Oshima T, Watari J, Miwa H.Effect of vancomycin treatment on colonic GLP-1/GRP 43 expression and gastrointestinal transit time.(session) The 4th Japan - Thailand Functional Gastrointestinal Disease Conference 2018.7 Nagoya
4. Mori S, Tomita T, Inoue Y, Nakai K, Tamura A, Kono T,Kondo T, Tozawa K, Oshima T, Fukui H, Watari J, Miwa H.A randomized double-blind placebo controlled trial on the effect of magnesium oxide in patients with chronic constipation.(Session) The 4th Japan - Thailand Functional Gastrointestinal Disease Conference 2018.7 Nagoya
5. Nakai K, Watari J, Mori S, Inoue Y, Tamura A, Kono T, Kondo T, Tozawa K, Tomita T,Oshima T, Fukui H, Miwa H.Sex differences in associations among metabolic syndrome, obesity, related biomarkers, and colorectal adenomatous polyp risk in a Japanese population.(session) The 4th Japan - Thailand Functional Gastrointestinal Disease Conference 2018.7 Nagoya
6. 三輪洋人.新しいGERD治療の考え方～なぜ胸やけが起こるのか？～.(特別講演) 第19回池田・川西地域連携消化器病研究会 2018.5 大阪
7. 三輪洋人.過敏性腸症候群(IBS)・便秘症UpData.(講演) 西宮市医師会学術講演会 2018.4 西宮
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■ Concurrent position
1. Kamikozuru Koji (Department of Inflammatory Bowl Disease, Division of Internal Medicine)
2. Tomita Toshihiko (Endoscope Center)
3. Horikawa Tomoki ()
4. Yokoyama Yoko (Department of Inflammatory Bowl Disease, Division of Internal Medicine,Intestinal Inflammation Research)
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